Introduction Liposomes as carriers of antibacterial drugs can significantly improve the distribution of antibacterial drugs in tissues and enhance the release of drugs at the target site, thus enhancing the antibacterial effect and reducing adverse reactions. And it can also overcome ...
TIMES OF RISING Latest Articles
On: December 20, 2023
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Peptides for Diabetes Research
Introduction to DiabetesDiabetes mellitus is a metabolic disease caused by multiple etiologies and characterized by chronic hyperglycemia. Abnormal metabolism of carbohydrates, fats, proteins, water and electrolytes due to defects in insulin secretion and/or action (insulin resistance). Types of DiabetesDiabetes can ...
On: November 22, 2023
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A Strategy for Site- and Chemoselective C-H Alkenylation through Osmaelectrooxidative Catalysis
Hydrocarbon activation has become a powerful tool in molecular science research and great progress has been made in molecular science research in recent years. In particular, weak O-coordinated carboxylic acid-assisted oxidative C-H cyclization was achieved by continuous breaking of C-H ...
On: November 22, 2023
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Polymer Materials in Healthcare
Modern healthcare would not be possible without the usage of many polymer-based medical products. Many things we take for granted such as exam gloves, syringes, intravenous (IV) blood bags and even most artificial organs, etc. are all made of polymers. ...
On: October 23, 2023
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Advances in siRNA Drug Research
siRNA, with a molecular weight of about 13 kDa, recruits the RNA-induced silencing complex (RISC) to mRNA through base pairing, thereby inhibiting protein translation (Fig. 1). The mRNA is targeted for cleavage through the catalysis of the RISC protein Ago2, ...
On: October 20, 2023
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Fermentation Production of ADC Payloads
Targeted therapies have significantly advanced the field of cancer therapy, and among these, antibody-drug conjugates (ADCs) have emerged as a viable therapeutic strategy. ADCs increase efficacy and decrease systemic toxicity by fusing the potency of cytotoxic drugs with the specificity ...
On: September 25, 2023
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Liposomes for Flavor and Fragrance Encapsulation
IntroductionFlavors are generally divided into natural flavors and artificial flavors, of which natural flavors are widely used, but natural flavors have low bioavailability, poor absorption, rapid metabolism, poor stability, easy oxidation, irritability, and other problems. In general, such problems can ...
On: May 22, 2023
In Vitro ADME
Assessing the absorption, distribution, metabolism, and excretion (ADME) of lead compounds during drug discovery and development is an essential component of drug preclinical development. The In vitro ADME studies provide key physicochemical and pharmacological properties that drive the safety and efficacy of ...
On: May 22, 2023
General Test Services
Pharmaceutical elemental analysis is very important for quality control and impurity control. Elemental pollutants have always been a key issue in drug development and production. Understanding the element composition of raw materials, active drug ingredients, excipients or preparations helps to ...
On: May 21, 2023
Aided Drug Design (CADD)
Prediction of ADMET (absorption, distribution, metabolism, excretion, and toxicity) is an essential step in drug design and drug screening. The ADME absorption distribution metabolism and excretion is considered a chemical compound within an organism. ADME/Tox prediction has been applied to investigate the ...
On: May 21, 2023
A Traceless Site-Specific Conjugation on Native Antibodies Enables Efficient One-Step Payload Assembly
Antibody-drug conjugates (ADCs) are composed of monoclonal antibodies targeting specific antigens and small-molecule cytotoxic drugs linked by linkers, which have both the powerful killing effect of traditional small-molecule chemotherapy and the tumor targeting of antibody drugs. Up to date, 14 antibody-drug ...
